The downtown Radisson Hotel is located at 200 N. Fourth Street in downtown St. Louis.  If you look at the map below, the hotel is where the green arrow is located (just north of Pine Street).  Fourth Street runs one way to the north (top of the map).  The entrance to the parking garage for the hotel is just to the north of the hotel.

If you are coming east to downtown on Highway 40 (I-64), you can go east to the last Missouri exit.  At the bottom of the ramp, turn left, and then turn left again (north) on Fourth Street.

If you are coming west from Illinois, cross the Poplar Street Bridge and then take Memorial Drive north to Pine Street.  Take a left on Pine (so that you are going west) and then take a right on Fourth Street.  You will be right at the Radisson.

If you have any questions, you can call the hotel at (314) 621-8200.